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Public Health England, the equivalent of the FDA in the U.K., stated in 2015 that while vaping may not be 100% safe, most of the chemicals causing smoking-related disease are absent and the chemicals that are present pose limited danger. This statement did not consider the fact that health effects of inhaling flavoring chemicals contained in popular e-cigarettes are completely unknown, or that heating liquids in these devices causes thermal decomposition of those e-cigarette chemicals that pose limited danger into known toxicants

The latest, published in mBio , finds that e-cigarette users have a unique oral microbiomethe community of bacteria and other microorganismsthat is less healthy than nonsmokers but potentially healthier than cigarette smokers, and measures worsening gum disease over time