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It has been found to inhibit synthesis and release of thyroid hormones, and may lead to increased destruction of thyroid cells
Reduced salivary secretion along with diminished buffering capacity and less attention to oral hygiene may lead to increased risk of dental caries and gingival disease

It is also theorized that any substance that decreases reactivity of brain receptors can lead to addiction vulnerability
Gastroesophageal Reflux Disease (GERD)Gastroesophageal reflux disease (GERD), also called acid reflux, can cause symptoms like heartburn, chest pain, regurgitation, and nausea