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The evidence: Success rates are 3-6% at one year

This is because, once it reaches the brain, it can trigger the release of beta-endorphin a hormone known for its ability to reduce anxiety, ease emotional distress and create a sense of well-being that makes it easier to get to sleep

Chaloupka for helpful comments, J

LAI risperidone has also been compared with zuclopenthixol in patients with schizophrenia and comorbid substance abuse in a randomized, open-label, 6-month study that reported a 34% reduction in the Positive and Negative Syndrome scale total score, an effect size that is almost identical to that observed in the CGI overall severity score here (i.e., a 36% reduction) [39]

PMC 4462043