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It also provides reassurance that very few adults and young people who have never smoked are becoming regular e-cigarette users (less than 1% in each group).However, the review raises concerns that increasing numbers of people think e-cigarettes are equally or more harmful than smoking (22.1% in 2015, up from 8.1% in 2013: ASH Smokefree GB survey) or dont know (22.7% in 2015, ASH Smokefree GB survey).Despite this trend all current evidence finds that e-cigarettes carry a fraction of the risk of smoking.Emerging evidence suggests some of the highest successful quit rates are now seen among smokers who use an e-cigarette and also receive additional support from their local stop smoking services.Professor Kevin Fenton, Director of Health and Wellbeing at Public Health England said:Smoking remains Englands number one killer and the best thing a smoker can do is to quit completely, now and forever.E-cigarettes are not completely risk free but when compared to smoking, evidence shows they carry just a fraction of the harm

Many studies have shown that smoking is one reason for a poor response to methotrexate, and that is dose-dependent