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A Pure Spliff This is the familiar cannabis joint, only without the added tobacco

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Lesions may vary in thickness, ranging from thin and homogenous (Figure 1) to thick and irregular (Figure 2)

Another effect of nicotine is the reduction in cerebral glucose utilization: prolonged exposure to nicotine, whether from traditional or e-cigarettes, induces an increase in the expression of GLUT1 in the brain, leading to a reduction in glycolysis, which causes a condition of glucose deprivation that increases the risk of stroke and worsens ischemic damage [111]