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Its why smokers go back to cigarettes even when they try to quit

L., Armeli, F., Leonardo, A., DAmico, A., Greco, E., Frati, G., Biondi-Zoccai, G., Spalice, A., Angeloni, A., Pignatelli, P., Violi, F., Zicari, A

By non-specifically activating cytokine-driven pathways of systemic inflammation, cigarette smoking may also play a role in lowering the threshold for SLE onset

156 It has been proposed that oxidative stress can inactivate HDAC2 by means of nitration or carboxylation and that HDAC2 is phosphorylated, ubiquitinated, and degraded as a consequence of cigarette smoke exposure

Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review