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10.1136/jitc-2020-002088 [DOI] [PMC free article] [PubMed] [Google Scholar] 60.Abou Khouzam R, Zaarour RF, Brodaczewska K, Azakir B, Venkatesh GH, Thiery J, et al

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Under normal physiological conditions, the removal of O mainly occurs through the antioxidant SOD, and SIRT3 is indispensable for the regulation of SOD activation and mitochondrial metabolism in mitochondria ( clearance and resulting in its excessive accumulation in the body ( ( production consumes the cofactor tetrahydrobiopterin necessary for eNOS activity ( The production of a large amount of ROS leads to the rapid inactivation of NO and the formation of peroxynitrite, thereby reducing the biological activity of NO ( Studies have shown that CSE can cause vascular wall contraction by activating Rho kinase (64, 65)

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