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[25] When smoking cigarettes, nicotine is absorbed into the lungs, from inhaling burning tobacco smoke
2 Indeed, by eliminating combustion, the levels of harmful chemicals are reduced on average by 95% in the THS aerosol compared to cigarette smoke

Nicotine & Tobacco Research, 11 (3), 323331

Zhang et al., 2018) which is also the reason for the difference in minor alkaloids
A clinical laboratory model for evaluating the acute effects of electronic 'cigarettes'