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Therefore, more men than women will have died from other smoking-related diseases during follow-up, before they could be diagnosed with CRC

These findings align with human studies, where an increased presence of Lachnospiraceae 26 , Prevotella 3 , Rikenellaceae , and Ruminococcaceae 27 has been reported in smokers compared to non-smokers

Daily smoking amount, duration of smoking, duration of cessation, and background of individuals may play a critical role in the impact of smoking cessation on endothelial function

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