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Compared to nicotine replacement, the disproportionality results (OR (95% CI)) were varenicline 8.4 (6.810.4), and bupropion 2.9 (2.33.7). Their conclusions: Varenicline shows a substantial, statistically significant increased risk of reported depression and suicidal/self-injurious behavior

Specifically, the recommendation is that: Any future film that shows or implies tobacco should be given an adult rating in the U.S., an R-rating

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Although the quality of evidence in the included reports was lacking, it has provided an overview of the available literature, potential pitfalls or challenges to study design, and was hypothesis-generating