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The significant effects identified in the primary analyses which retained odds ratios and confidence intervals entirely outside of the null across all sensitivity analyses were as follows: Intention to make a quit attempt, compared to wanting withdrawal management or declining the intervention, which was associated with increased odds of being a non-smoker at 180 days, and lower odds of death between 31 days and 1 year post-discharge Medium nicotine dependence (HSI scores 24), compared to low nicotine dependence, which was associated with decreased odds of being a non-smoker at 180 days Ethnicity categorised as Mixed, Asian, or Other, which was associated with decreased odds of being a non-smoker at 180 days Being aged 1639 (compared to those aged over 60), or being female, which were both associated with reduced odds of death between 31 days and 1 year post-discharge A diagnosis of cancer, diabetes, or mental/behavioural disorder, which were all associated with increased odds of death between 31 days and 1 year post-discharge A diagnosis of cancer, COPD, CVD, or mental/behavioural disorder, which were all associated with increased odds of readmission between 31 days and 1 year post-discharge Discussion Over a 12-month period, among the cohort of 2067 patients who smoked and were assessed by a TDS during admission to one of two major acute London teaching hospitals, the majority (79%) accepted tobacco dependence treatment based on the Ottawa Model of Smoking Cessation (OMSC)