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PA then diffuses back into the bacilli, where it accumulates and exerts multiple effects against Mtb, including inhibition of fatty acid synthase, disruption of membrane potential, and interference with energy production by interacting with ribosomal protein S1 to inhibit trans-translation (Boshoff, Mizrahi, and Barry, 2002

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On July 23, 2024, the citys Air Quality Index (AQI) score reached 227 AQI, the first time it has crossed into the very unhealthy category in a quarter century