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Louis UL1TR002345: Institute of Clinical and Translational Sciences, Weill Medical College of Cornell University UL1TR002384: Weill Cornell Medicine Clinical and Translational Science Center, West Virginia University U54GM104942: West Virginia Clinical and Translational Science Institute (WVCTSI) Submitted: Icahn School of Medicine at Mount Sinai UL1TR001433: ConduITS Institute for Translational Sciences, The University of Texas Health Science Center at Tyler UL1TR003167: Center for Clinical and Translational Sciences (CCTS), University of California, Davis UL1TR001860: UCDavis Health Clinical and Translational Science Center, University of California, Irvine UL1TR001414: The UC Irvine Institute for Clinical and Translational Science (ICTS), University of California, Los Angeles UL1TR001881: UCLA Clinical Translational Science Institute, University of California, San Diego UL1TR001442: Altman Clinical and Translational Research Institute, University of California, San Francisco UL1TR001872: UCSF Clinical and Translational Science Institute NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository Core OTA-21-015A: Post-Acute Sequelae of SARS-CoV-2 Infection Initiative (RECOVER) Pending: Arkansas Childrens Hospital UL1TR003107: UAMS Translational Research Institute, Baylor College of Medicine None (Voluntary), Childrens Hospital of Philadelphia UL1TR001878: Institute for Translational Medicine and Therapeutics, Cincinnati Childrens Hospital Medical Center UL1TR001425: Center for Clinical and Translational Science and Training, Emory University UL1TR002378: Georgia Clinical and Translational Science Alliance, HonorHealth None (Voluntary), Loyola University Chicago UL1TR002389: The Institute for Translational Medicine (ITM), Medical College of Wisconsin UL1TR001436: Clinical and Translational Science Institute of Southeast Wisconsin, MedStar Health Research Institute None (Voluntary), Georgetown University UL1TR001409: The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS), MetroHealth None (Voluntary), Montana State University U54GM115371: American Indian/Alaska Native CTR, NYU Langone Medical Center UL1TR001445: Langone Healths Clinical and Translational Science Institute, Ochsner Medical Center U54GM104940: Louisiana Clinical and Translational Science (LA CaTS) Center, Regenstrief Institute UL1TR002529: Indiana Clinical and Translational Science Institute, Sanford Research None (Voluntary), Stanford University UL1TR003142: Spectrum: The Stanford Center for Clinical and Translational Research and Education, The Rockefeller University UL1TR001866: Center for Clinical and Translational Science, The Scripps Research Institute UL1TR002550: Scripps Research Translational Institute, University of Florida UL1TR001427: UF Clinical and Translational Science Institute, University of New Mexico Health Sciences Center UL1TR001449: University of New Mexico Clinical and Translational Science Center, University of Texas Health Science Center at San Antonio UL1TR002645: Institute for Integration of Medicine and Science, Yale New Haven Hospital UL1TR001863: Yale Center for Clinical Investigation Funding This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH)

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Second, barely one year after the Deeming Rule became final, FDA substantially deregulated e-cigarettes by issuing a Guidance purporting to suspend premarket review of e-cigarettes that were on the market as of the effective date of the Deeming Rule by extending the deadline for filing PMTAs for four years (until August 2022)