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For instance, the Royal College of Physicians has said: Nicotine is not, however, in itself, a highly hazardous drug, adding, [] it is inherently unlikely that nicotine inhalation itself contributes significantly to the mortality or morbidity caused by smoking, The 2016 report goes on: The main culprit is smoke and, if nicotine could be delivered effectively and acceptably to smokers without smoke, most if not all of the harm of smoking could probably be avoided. Marketing to the intended audience only Its vital better alternatives to smoking dont fall into the wrong hands

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5) where statistical tests were paired and one-sided (we test hypotheses driven by nicotine effect and model)

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