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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Coyle CE, Dugan E

Abnormal regional brain activity has been revealed in mesolimbic dopamine reward circuits, including the ventral tegmental area, nucleus accumbens, hippocampus, amygdala, cingulate, thalamus, striatum, and prefrontal cortex, as well as visuospatial attention circuits, including the dorsolateral and ventrolateral prefrontal cortex, parietal cortex, and extra-striate visual cortex in smokers 15, 16

He was overweight, out of shape, a chain-smoker since high school, drank heavily and was promiscuous

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In addition, a study by Romundstad et al