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A nicotine/smoking dose-response association has been observed for some bacterial taxa in gut flora, with an increasing mean relative abundance of specific taxa as cigarette packs per day increased 15

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Kenford SL, Fiore MC, Jorenby DE, Smith SS, Wetter D, Baker TB (1994)

However, in order to fully protect youth, the Heath Equity Impact Assessment work-group recommended ensuring that the licensing system include sustainable funding for enforcement (e.g