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Methods Antibodies and reagents Antibodies against ubiquitin and IL-1 were obtained from Cell Signaling Technology (Danvers, MA)

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Physical examination revealed dry skin, areas of atrophic skin with a cigarette-paper-like appearance, sun-tan-like hyperpigmentation, and telangiectasias predominantly in photo-exposed areas, as well as pseudosyndactyly of the hands and punctate keratotic papules on the soles of the feet (Figs

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