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Neurons have five types of voltage dependent calcium channels based on voltage requirements: L-type that directs skeletal muscles, cardiac related muscle cells, endocrine cells, adrenal, etc., associated with contraction, hormone release and synaptic integration (neurons working together) P/Q-type that activate neurons and neurotransmitter and hormone release N-type works at the nerve terminals similarly to P/Q for neurotransmitter and hormone release T-type think of it as the pacemaker of the brain for firing with a particular frequency R-type that works with cerebral cells and some neurons For each of these, the current required is different so fine-tuning is necessary

Yang, J., Balbo, S., Villalta, P

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For example, the Elderly Simplified Application Project is a SNAP demonstration project that 23 states have participated in