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In 2009, the FDA issued an alert to healthcare professionals reporting that cases of neuropsychiatric symptoms have occurred in patients without pre-existing psychiatric illness and have worsened in patients with pre-existing psychiatric illness [45]

Search strategy for identification of studies: For the identification of the studies included in this review, we devised the search strategy for each database

Appendix A describes the IQOS Tobacco Heating System, Appendix B briefly summarizes the Tobacco Master Settlement Agreement of 1998, Appendix C provides definitions of terms used in this report, and Appendix D provides acronyms used in this report

NAFLD itself exists on a spectrum, ranging from simple steatosis (fat accumulation alone) to non-alcoholic steatohepatitis (NASH), where inflammation and liver cell damage occur alongside fat accumulation

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