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This group of ichthyoses is caused by dominant variants in KRT136 or KRT10.36 Those caused by variants in KRT1 commonly present palmoplantar keratoderma (Fig
The magnitude of these changes was similar to changes found in individuals who smoked cigarettes, galvanizing the idea that passive exposure to polluted air is not simply a nuisance or temporary inconvenience, but represents a truly significant personal health hazard, even today in some of most developed and sophisticated regions of the world
doi: 10.1093/ntr/ntab192 89
