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Au said the fact that vapes are more popular among young people and less well-studied than cigarettes is all the more reason to discourage their use

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At a molecular level, smoking affects key signaling pathways such as nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinases (MAPK) and induces epigenetic modifications like DNA methylation and histone modification [22]

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[37, 38] found that an acrolein concentration in the lung of an e-cigarette user is 16-fold higher than that in the breathing air recommended World Health Organization (WHO) threshold and 320-fold higher than the US Environmental Protection Agency (EPA) threshold