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Some observational studies suggest that patients with NAFLD who continue using tobacco products may have higher rates of advanced fibrosis compared to non-users with similar metabolic profiles, though the strength of evidence specific to smokeless tobacco remains uncertain

Additionally, the aforementioned review regarding psychotropic medications notes that it is possible for patients to fail to notice their side effects or resist disclosing their use of cannabis to researchers, which may contribute to the lack of documented interactions

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However, whole life can be a good fit for high-net-worth individuals , people with long-term financial responsibilities, or people with dependents who require lifelong care, such as an aging parent or a child with a disability