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Nicotine affects the sleep-wake cycle and its absence can lead to difficulties falling asleep or staying asleep

J Behav Med 12 , 15982 (1989)

Additionally, chewing tobacco can lead to nicotine addiction at a more intense level due to its high nicotine content and prolonged exposure

27 These risks are not necessarily linear, 2 although some of the nonlinear effects that have been documented may reflect the fact that self-reported daily cigarette consumption is not a perfect marker for exposure, given that people may get more or less nicotine (and with it, harmful substances) out of each cigarette they smoke

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