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Nicotine crosses the placenta readily, 77 and levels in fetal serum and AF have been reported to be higher than in corresponding maternal serum

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189 Adverse Behavioral Outcomes in Human Studies Although the nature of human research is fundamentally different from that using animal models, the evidence provided by human studies also strongly suggests that exposure to tobacco smoke, both prenatally and postnatally, increases the risk of poor behavioral and cognitive outcomes in children