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These thin sheets used to encase tobacco or other substances play a critical role in the smoking experience

[52] Stimulation of the brain [edit] Nicotine is a parasympathomimetic stimulant [8] that binds to and activates nicotinic acetylcholine receptors in the brain, [9] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [10] and several neuropeptides, including proopiomelanocortin-derived -MSH and adrenocorticotropic hormone

Altria Group, which owns Marlboro in the United States, and PMI, which owns the brand elsewhere, have both faced declining revenue from combustible products

doi:10.1093/ntr/nts178