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Substance Misuse and the Kidneys: Effects of Drugs on the Kidneys The Function of the Kidneys and Renal System The kidneys, which are part of the renal system, filter blood to remove waste and excess water via myriad filtering units called nephrons, each of which has a glomerulus and a tubule

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3.1 Endothelial dysfunction Various clinical and laboratory studies have shown that endothelial dysfunction induced by cigarette smoke is mediated by decreased nitric oxide (NO) bioavailability, increased production of superoxide anions, and increased production and release of endothelin ( 28 )