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Nicotine from a smoked cigarette will reach the brain in as little as 7 seconds after inhalation. The addictive effect of nicotine is linked to its capacity to trigger the release of dopamine a chemical in the brain that is associated with feelings of pleasure

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Behavioral interventions must address the challenge of peer influence, which can often counteract cessation efforts

They should verify classification, label wording, alcohol content statements, and the applicable agency pathway before selling in the United States

This has spurred the development of nicotine replacement therapies and harm reduction strategies