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Supplementary Material FUNDING: This work was supported in part by the National Heart, Lung, and Blood Institute of the National Institutes of Health and the Center for Tobacco Products of the U.S

Huge shutters operated by pulleys would help regulate the temperature and humidity, depending on weather and smoke

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Nicotine patches deliver a controlled amount of nicotine into the body through the skin

[71] It seems that experienced users like to adopt the e-cigarette to their (inhalation) needs, leading to e-cigarettes with adjusted airflow inlet using atomizer heads with different sized air holes