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It is also important to recognize that cigarette smokers typically take 8-10 puffs over 5-8 minutes resulting in an arterial spike of nicotine levels, whereas most e-cigarette use is intermittent throughout the day, resulting in lower and more stable nicotine levels and no arterial spikes

Parallel evidence from studies of e-cigarettes tells a similar story

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Chocolate Cigars This chunky rolled wafer is generously smothered in melted chocolate

Chop that mixture into powder, and smoke it in a clay