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To relax the log(linear) assumption usually applied to continuous doseresponse risk and make the estimates robust to the placement of spline knots, we used an ensemble spline approach to fit the functional form of the doseresponse relationship

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Still, he and his coauthors concluded, their findings provide preliminary evidence that a substantial reduction in nicotine content is associated with reduced smoking, nicotine exposure and nicotine dependence without serious adverse effects, including nicotine withdrawal