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In doing so daily, they get addicted to smoking because of the nicotine, which serves as a drug, and they do not easily quit smoking

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Regardless of the causative pathway (or combination thereof), integrating structural and functional neuroimaging results may provide insight into the neurobiological processes potentially contributing to the initiation, escalation, and/or maintenance of cigarette smoking

The harmful chemicals within a cigarette include some of the following: Arsenic (rat poison), Tar (what they make roads out of), Benzene Aromatic Amines, Beryllium (a toxic metal), Cadmium (a toxic metal) (1), 1,3Butadiene (a hazardous gas) and Cyanide (the same chemical use in gas chambers in WW2)

As smoking tends to aggregate between spouses (smokers are more likely to marry smokers), misclassification of active smoking would tend to be differential on the basis of spousal smoking (the exposure under investigation)