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Until the date of the first encounter between Amerindians and Europeans at the very end of the fifteenth century, no society outside of North and South America had any idea of its existence. (Jordan Goodman, Webs of Dependence: Towards a Political History of Tobacco, Ashes to Ashes: The History of Smoking and Health , 1998, p

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LH is the main tropic regulator of Leydig cell function without which androgen production is not possible.[14] The observed decrease in serum testosterone level of rats treated with the two doses of nicotine is not associated with a decrease in LH thus suggesting that the etiology is not associated with a disorder in the pituitary but rather a testicular dysfunction, which is indicated when low serum testosterone levels are accompanied by high levels of serum LH