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, reversed the increase in p53 and Bax in aged rats by restoring antioxidant defense status through increasing the levels of enzymes (SOD, CAT, GPx, etc.) and nonenzymatic antioxidants (GSH, vitamin C, vitamin E, etc.), resulting in the amelioration of aging-mediated testicular impairment ( Second, p53 can be activated by DNA damage induced by ROS

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