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Policy interventions such as increased taxes on cigarettes, bans on cigarette advertising and promotions (eg, free packs of cigarettes) and regulation of cigarette labelling have contributed to dramatic reductions in cigarette smoking in various countries.122126 Since these policies are effective, they were incorporated into the Framework Convention on Tobacco Control (FCTC), the WHO's first international treaty.127129 The FCTC outlines evidence-based tobacco control policies that, if implemented properly, have the potential to reduce tobacco use

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the magnitude of the effect of cigarette smoking outweighs all other factors

The sweet spot on the THR model is where RRPs are substantially lower than cigarettes in toxicity/harmfulness, relatively high in appeal to current tobacco users but not adversely impacting initiation by non-smokers including youths (Smith et al., 2016

Price increases have been shown to have the largest impact on youth initiation into tobacco use and quitting, Koenemann has said