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Commonly prescribed serotonergic antidepressants, including selective serotonin reuptake inhibitors (SSRIs), venlafaxine and trazodone, do not improve common psychological symptoms in people with substance use disorders, including alcohol use disorder

Practically, they just disappear from the game entirely with a minimalistic VFX, but it works just fine and can arguably even cause a very minor, but still, performance and stability improvement impact for your save in a long-term

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Yes, using a filter with a joint makes a significant difference by trapping tar, resin, and contaminants