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A phase III, randomized, double-blind, placebo-controlled trial in 386 subjects with a history of nonmelanoma skin cancer recently examined the effect of daily nicotinamide supplementation (1 g) for 12 months on skin cancer recurrence at three-month intervals over an 18-month period (66)

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Also, the liver of these mice exhibited reduced GLUT2 protein levels and lower phosphorylation of Akt and GS, which could be related to the diminished glycogen levels observed (112)

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