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There was no association between maternal smoking (at any time during pregnancy) and other congenital anomalies not depicted in the Figure, including Down Syndrome, spina bifida, and anencephaly

The connection is hard to ignore

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CDP-choline treatment reduced serum nicotine and cotinine concentrations, normalized adrenaline and -endorphin levels, and improved behavioral outcomes, as indicated by increased time spent in the light chamber and reduced stretching frequency

Ultrasound images from this study showed babies grimacing and having a greatly increased mouth and hand movement in reaction to nicotine exposure