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This helps the FDA to develop science-based regulatory policies that will reduce addiction.

Current e-cigarette use among middle and high school students declined significantly between 2023 and 2024 (7.7% to 5.9%, or 2.13 million to 1.63 million) but e-cigarette use remains a serious public health threat: among students who currently used e-cigarettes in 2024, 38.4% reported frequent use and 26.3% reported daily use

The Georgia Department of Revenue conducts compliance checks and enforces the law continuously to ensure retailers are following federal and state Tobacco 21 laws that prohibit the sale of all tobacco products to those under 21

This natural heterogeneity complicates efforts to isolate the specific effects of smoking, as it becomes difficult to discern whether observed changes in microbial composition are due to smoking itself or interactions between smoking and other factors

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