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Western blot analysis showed that, compared with the CSE treatment group, the expressions of Sp1 and SIRT1 in the cells transfected with the miR-125a-5p inhibitor increased, the level of HIF-1 acetylation decreased, and the cell senescence markers p21 and p27 were down-regulated

Many factors influence development of coronary artery disease and heart attacks, and cholesterol is an important one, says James Cireddu, MD, medical director of University Hospitals Harrington Heart & Vascular Institute at UH Bedford Outpatient Campus, UH Regional Hospitals

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