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Psychopharmacology 166 , 306313 (2003)

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The genome of spermatozoa can undergo changes and mutation due to endogenous and exogenous agents which, in the case of inappropriate repair, leads to production of morphologically abnormal sperms, reduced spermatozoid (oligospermia), and absence of spermatozoid (azoospermia), culminating in male infertility [4,5,6].Typically, during spermatogenesis in mammalian testicles, the process of apoptosis of germ cells that occurs spontaneously can act as a normal physiological mechanism followed by abnormal germ cells elimination, after which finally high-quality sperms are produced [7]

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