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Oxidative stress and genetic polymorphisms in antioxidant enzymes such as glutathione transferases (GSTs) are significant contributors to the development of ASD (Mandic-Maravic et al., 2019)

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Grading of recommendations Recommendations are graded according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system.21 Whether a recommendation is strong or conditional will depend on considerations such as certainty in estimated effects of an intervention, including magnitude, as well as estimates of how patients value and prioritize outcomes, variability of these estimates, and wise use of resources
