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These chemicals enter tobacco products through multiple routes: Naturally occurring in the tobacco plant: Tobacco plants produce biological chemicals such as nicotine (the main addictive substance), polyphenols (which affect flavor), and toxic metals absorbed from the soil

Previous studies have shown that inhalant abuse is usually initiated during preadolescence [27] and chewing tobacco often begins in adulthood [28]

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Japanese customs authorities take undeclared items seriously, and penalties can include fines, confiscation of the items , or even legal action depending on the severity of the violation

The data on the existence of tobacco endgame goals and strategies were complemented as needed by information provided in the answers gathered with the JATC2 WP9 questionnaire on tobacco endgame strategies