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Nicotine also influences the brains reward system, increasing the risk of addiction and potentially enhancing the pleasurable effects of other substances, such as cocaine and methamphetamine [9,25]

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2.2 Tobacco Samples The oral tobacco products were purchased or acquired between May 2007 and May 2009

Electronic cigarettes Electronic cigarettes (ECs), developed as a safer alternative to traditional cigarettes, were initially hypothesized to reduce nicotine dependence and diminish adverse health effects due to the absence of tar and incomplete combustion byproducts

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