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Liu BQ, Peto R, Chen ZM, Boreham J, Wu YP, Li JY, Campbell TC, Chen JS

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A 2025 study found that users who had completely switched from cigarettes to IQOS for two or more years showed favorable differences across all nine biomarkers of potential harm (e.g., endothelial function, platelet activation, oxidative stress), compared to continuing smokers, with IQOS users values approaching those observed in former smokers