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One category is DNA contact mutations, which occur in amino acids in contact with DNA, resulting in the inability of p53 to bind to DNA, such as p53 R273H and R248Q mutants

The development of GEMMs has allowed for insights into the biology of p53 mutant cancers, as they reliably mimic the oncogenic mutations underpinning cancer formation in humans and hence enable the study of the impact of specific oncogenic driver events

The industry consolidation during this period ultimately led to the outright purchase of the American Tobacco Company by Brown & Williamson in 1994

J Inflamm (Lond)

[11] Early life and education [edit] David Khari Webber Chappelle was born on August 24, 1973, in Washington, D } : CS1 maint: numeric names: authors list (link) "Dave Chappelle returns to SNL, jokes about Kanye and antisemitism"