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2017 in Scientific Evidence for the Addictiveness of Tobacco and Smoking Cessation in Tobacco Litigation.
Studies show that smoke exposure reduces macrophage phagocytic ability by downregulating key recognition receptors and MFG-E8, a crucial bridging molecule for apoptotic cell clearance 61
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Ia: Systematic review/meta-analysis Ib: Randomized controlled trial IIa: Non-randomized controlled trial or large-scale cohort study ( n 500) IIb: Analytic epidemiologic study: small-scale cohort, case-control, or cross-sectional III: Descriptive study: case report or case series report IV: Laboratory experiments and others Criteria for recommendations and consensus building A draft version of this document was distributed to each Working Group member for review and comments
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