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Finally, the sensitivity analysis results from application of human toxicity data for some of the compounds (alcohol, nicotine and THC 21,55,56,57 ) are shown in Supplementary Table S3 online and marked in Figures 13

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Summary Keywords adolescents, e-cigarettes, nicotine addiction, prevention strategies, public health, vaping Citation Fainardi V, Barbetta E, Petz M, Rizzo L, Ruberti F and Esposito S (2026) The new nicotine epidemic: understanding the systemic harms of e-cigarettes in the adolescent population