cigarette smoke induces cytoplasmic p53 accumulation The role of smoke-induced epigenetic alterations in inflammation | Epigenetics & Chromatin Mitochondrial DNA is a key
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doi: 10.1016/j.bbcan.2020.188393 87 DaviesLSpillerDWhiteMRGriersonIParaoanL
In conclusion, this review emphasizes the critical role of p53 as a key target in SC prevention, reinforcing the need for further research in this area to prompt the use of p53 chemopreventive agents to counteract the growing number of SC cases
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Additionally, the photoprotective effects of 1,25(OH)2D3 was demonstrated in keratinocytes and UV-irradiated skin mice, with a reduction of CPDs and nitric oxide derivatives, and increased p53 expression [140]
