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In a study of a small subset of schizophrenia studies, researchers found that age at onset was associated with symptoms in both men and women
My 86 year old grandmother smokes and shes ok

J Pharmacol Exp Ther 294 : 239247
And while both have been found to help sustain long-term smoking efficacy, bupropion is considered less effective than varenicline in its ability to do so

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