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And Melqua watched her until all light faded from those large eyes, and she collapsed into a handful of sticks curled into a tight ball at the end of the cot - a sharp cat with tufty brown hair and coca stains on her teeth

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Compounds which have bronchodilating properties (opening/broadening the airways) would enable the smoker to inhale deeper (a larger volume of) tobacco smoke implying an increase in the bioavailability of nicotine

You could take the same amount of tobacco that a moderate smoker might smoke, and if you infuse that into alcohol, youd have very bad results. Even chewing or eating tobacco will produce different, and possibly more limited, effects than consuming an alcohol-based extract